Drug interactions
Brompheniramine + Buprenorphine subdermal implant
Severity: Moderate
Brompheniramine and Buprenorphine subdermal implant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sedating antihistamines add to the CNS depressant effect of buprenorphine, increasing drowsiness and impaired coordination. Respiratory depression is a concern, particularly if other depressants are also taken.
What this interaction means in plain words
Brompheniramine and Buprenorphine subdermal implant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression via opioid receptor agonism and H1 antagonism.
What to do
Monitor for excessive sedation and reduced respiratory rate, and advise against driving until the response is known. Choose a non-sedating antihistamine when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Buprenorphine subdermal implant?
MediHelp rates the interaction as moderate. Brompheniramine and Buprenorphine subdermal implant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sedating antihistamines add to the CNS depressant effect of buprenorphine, increasing drowsiness and impaired coordination. Respiratory depression is a concern, particularly if other depressants are also taken.
How serious is the interaction between Brompheniramine and Buprenorphine subdermal implant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and reduced respiratory rate, and advise against driving until the response is known. Choose a non-sedating antihistamine when feasible.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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