Drug interactions
Brompheniramine + Buprenorphine transdermal
Severity: Moderate
Brompheniramine and Buprenorphine transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine can intensify the sedation and psychomotor impairment produced by transdermal buprenorphine. Because patch levels persist for days, the effect cannot be quickly reversed and respiratory depression may occur.
What this interaction means in plain words
Brompheniramine and Buprenorphine transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression via opioid receptor agonism and H1 antagonism.
What to do
Monitor sedation and respiratory rate, especially after starting or increasing brompheniramine. Use a non-sedating antihistamine where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Buprenorphine transdermal?
MediHelp rates the interaction as moderate. Brompheniramine and Buprenorphine transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine can intensify the sedation and psychomotor impairment produced by transdermal buprenorphine. Because patch levels persist for days, the effect cannot be quickly reversed and respiratory depression may occur.
How serious is the interaction between Brompheniramine and Buprenorphine transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory rate, especially after starting or increasing brompheniramine. Use a non-sedating antihistamine where possible.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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