Drug interactions
Brompheniramine + Buprenorphine
Severity: Moderate
Brompheniramine and Buprenorphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sedating antihistamines add to opioid-induced drowsiness and psychomotor impairment. Anticholinergic effects such as dry mouth, constipation and urinary retention may also be additive.
What this interaction means in plain words
Brompheniramine and Buprenorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Buprenorphine belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid and H1 antihistamine effects.
What to do
Monitor for oversedation and advise against driving or alcohol. Consider a non-sedating antihistamine instead.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Buprenorphine?
MediHelp rates the interaction as moderate. Brompheniramine and Buprenorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sedating antihistamines add to opioid-induced drowsiness and psychomotor impairment. Anticholinergic effects such as dry mouth, constipation and urinary retention may also be additive.
How serious is the interaction between Brompheniramine and Buprenorphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and advise against driving or alcohol. Consider a non-sedating antihistamine instead.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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