Drug interactions
Brompheniramine + Butabarbital
Severity: Moderate
Brompheniramine and Butabarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates and sedating antihistamines both depress the CNS, so together they cause greater drowsiness, confusion and impaired performance. Respiratory depression can occur at higher doses.
What this interaction means in plain words
Brompheniramine and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A enhancement and H1 receptor blockade.
What to do
Avoid combining where possible; if needed, use reduced doses and monitor sedation. Advise against driving and alcohol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Butabarbital?
MediHelp rates the interaction as moderate. Brompheniramine and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates and sedating antihistamines both depress the CNS, so together they cause greater drowsiness, confusion and impaired performance. Respiratory depression can occur at higher doses.
How serious is the interaction between Brompheniramine and Butabarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if needed, use reduced doses and monitor sedation. Advise against driving and alcohol use.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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