Drug interactions
Brompheniramine + Butorphanol
Severity: Moderate
Brompheniramine and Butorphanol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sedating antihistamines add to opioid-induced drowsiness and psychomotor impairment. Older adults are particularly susceptible to confusion and falls.
What this interaction means in plain words
Brompheniramine and Butorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Butorphanol belongs to Musculoskeletal.
Why it happens
Additive CNS depression from central H1-receptor blockade and opioid receptor activation.
What to do
Advise avoiding driving and alcohol; consider a non-sedating antihistamine if one is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Butorphanol?
MediHelp rates the interaction as moderate. Brompheniramine and Butorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sedating antihistamines add to opioid-induced drowsiness and psychomotor impairment. Older adults are particularly susceptible to confusion and falls.
How serious is the interaction between Brompheniramine and Butorphanol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding driving and alcohol; consider a non-sedating antihistamine if one is needed.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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