Drug interactions
Brompheniramine + Chlordiazepoxide
Severity: Moderate
Brompheniramine and Chlordiazepoxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a first-generation sedating antihistamine, and with a benzodiazepine it can increase drowsiness, slow reaction time and cause confusion. Anticholinergic effects add to the burden in older adults.
What this interaction means in plain words
Brompheniramine and Chlordiazepoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Chlordiazepoxide belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and central H1 receptor blockade.
What to do
Avoid driving and alcohol, and consider a non-sedating antihistamine. Use lower doses in older adults and monitor for confusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Chlordiazepoxide?
MediHelp rates the interaction as moderate. Brompheniramine and Chlordiazepoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a first-generation sedating antihistamine, and with a benzodiazepine it can increase drowsiness, slow reaction time and cause confusion. Anticholinergic effects add to the burden in older adults.
How serious is the interaction between Brompheniramine and Chlordiazepoxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid driving and alcohol, and consider a non-sedating antihistamine. Use lower doses in older adults and monitor for confusion.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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