Drug interactions
Brompheniramine + Clemastine
Severity: Moderate
Brompheniramine and Clemastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two first-generation antihistamines used together duplicate therapy and increase sedation, cognitive impairment and anticholinergic effects such as dry mouth and urinary retention.
What this interaction means in plain words
Brompheniramine and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Clemastine belongs to Respiratory.
Why it happens
Additive central H1-receptor antagonism and muscarinic blockade.
What to do
Use only one sedating antihistamine at a time. Counsel on drowsiness and avoid driving if affected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Other interactions of Clemastine
Frequently asked questions
Can I take Brompheniramine with Clemastine?
MediHelp rates the interaction as moderate. Brompheniramine and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Two first-generation antihistamines used together duplicate therapy and increase sedation, cognitive impairment and anticholinergic effects such as dry mouth and urinary retention.
How serious is the interaction between Brompheniramine and Clemastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only one sedating antihistamine at a time. Counsel on drowsiness and avoid driving if affected.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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