Drug interactions
Brompheniramine + Diazepam intranasal
Severity: Moderate
Brompheniramine and Diazepam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal diazepam combined with a sedating antihistamine can produce additive sedation, dizziness and impaired coordination. Respiratory depression may occur, particularly after a seizure rescue dose.
What this interaction means in plain words
Brompheniramine and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A enhancement and H1 blockade.
What to do
Monitor respiratory status and level of consciousness after diazepam use. Avoid brompheniramine when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Diazepam intranasal?
MediHelp rates the interaction as moderate. Brompheniramine and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intranasal diazepam combined with a sedating antihistamine can produce additive sedation, dizziness and impaired coordination. Respiratory depression may occur, particularly after a seizure rescue dose.
How serious is the interaction between Brompheniramine and Diazepam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory status and level of consciousness after diazepam use. Avoid brompheniramine when possible.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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