Drug interactions
Brompheniramine + Difenoxin
Severity: Moderate
Brompheniramine and Difenoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difenoxin is an opioid antidiarrheal and its CNS depressant effects can be increased by sedating antihistamines. Drowsiness and, at higher doses, respiratory depression may result.
What this interaction means in plain words
Brompheniramine and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Difenoxin belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression via opioid agonism and H1 antagonism.
What to do
Monitor for oversedation and avoid exceeding recommended difenoxin doses. Counsel against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Other interactions of Difenoxin
Frequently asked questions
Can I take Brompheniramine with Difenoxin?
MediHelp rates the interaction as moderate. Brompheniramine and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difenoxin is an opioid antidiarrheal and its CNS depressant effects can be increased by sedating antihistamines. Drowsiness and, at higher doses, respiratory depression may result.
How serious is the interaction between Brompheniramine and Difenoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and avoid exceeding recommended difenoxin doses. Counsel against driving.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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