Drug interactions
Brompheniramine + Donepezil transdermal
Severity: Moderate
Brompheniramine and Donepezil transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine has anticholinergic activity that opposes the cholinesterase inhibition of donepezil, potentially reducing cognitive benefit. Sedating antihistamines may also worsen confusion in dementia patients.
What this interaction means in plain words
Brompheniramine and Donepezil transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism between muscarinic blockade and increased acetylcholine.
What to do
Avoid anticholinergic antihistamines in patients on donepezil and use a non-sedating alternative. Monitor cognition and behavior if unavoidable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Donepezil transdermal?
MediHelp rates the interaction as moderate. Brompheniramine and Donepezil transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine has anticholinergic activity that opposes the cholinesterase inhibition of donepezil, potentially reducing cognitive benefit. Sedating antihistamines may also worsen confusion in dementia patients.
How serious is the interaction between Brompheniramine and Donepezil transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid anticholinergic antihistamines in patients on donepezil and use a non-sedating alternative. Monitor cognition and behavior if unavoidable.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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