Drug interactions
Brompheniramine + Droperidol
Severity: Moderate
Brompheniramine and Droperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droperidol is sedating, and brompheniramine adds further CNS depression. Droperidol also prolongs the QT interval, so the combination needs attention to both sedation and cardiac rhythm.
What this interaction means in plain words
Brompheniramine and Droperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from dopamine and histamine receptor blockade; droperidol additionally blocks cardiac potassium channels.
What to do
Monitor the level of sedation and ECG when droperidol is given with a sedating antihistamine. Correct potassium and magnesium before use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Droperidol?
MediHelp rates the interaction as moderate. Brompheniramine and Droperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Droperidol is sedating, and brompheniramine adds further CNS depression. Droperidol also prolongs the QT interval, so the combination needs attention to both sedation and cardiac rhythm.
How serious is the interaction between Brompheniramine and Droperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the level of sedation and ECG when droperidol is given with a sedating antihistamine. Correct potassium and magnesium before use.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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