Drug interactions
Brompheniramine + Epinephrine
Severity: Minor
Brompheniramine and Epinephrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine's stimulant effects may partly oppose brompheniramine's sedation, with an unpredictable net result. The two are sometimes used together in allergic reactions, in which epinephrine remains the essential treatment.
What this interaction means in plain words
Brompheniramine and Epinephrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brompheniramine belongs to Respiratory; Epinephrine belongs to Endocrine.
Why it happens
Opposing central effects; no established pharmacokinetic interaction.
What to do
Do not delay epinephrine in anaphylaxis because of antihistamine use. Monitor heart rate and blood pressure after dosing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brompheniramine
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Brompheniramine with Epinephrine?
MediHelp rates the interaction as minor. Brompheniramine and Epinephrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Epinephrine's stimulant effects may partly oppose brompheniramine's sedation, with an unpredictable net result. The two are sometimes used together in allergic reactions, in which epinephrine remains the essential treatment.
How serious is the interaction between Brompheniramine and Epinephrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not delay epinephrine in anaphylaxis because of antihistamine use. Monitor heart rate and blood pressure after dosing.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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