Drug interactions
Brompheniramine + Esketamine intranasal
Severity: Moderate
Brompheniramine and Esketamine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation and dissociation, and sedating antihistamines like brompheniramine can add to drowsiness and psychomotor impairment. The combination may make post-dose monitoring more difficult.
What this interaction means in plain words
Brompheniramine and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Monitor sedation level during the post-administration observation period. Avoid routine sedating antihistamines on treatment days when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Esketamine intranasal?
MediHelp rates the interaction as moderate. Brompheniramine and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine causes sedation and dissociation, and sedating antihistamines like brompheniramine can add to drowsiness and psychomotor impairment. The combination may make post-dose monitoring more difficult.
How serious is the interaction between Brompheniramine and Esketamine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level during the post-administration observation period. Avoid routine sedating antihistamines on treatment days when possible.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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