Drug interactions
Brompheniramine + Esketamine
Severity: Moderate
Brompheniramine and Esketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating antihistamine, and with esketamine may increase drowsiness and impair alertness and coordination.
What this interaction means in plain words
Brompheniramine and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Esketamine belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 antagonism and NMDA antagonism.
What to do
Avoid sedating antihistamines around esketamine sessions, or consider a non-sedating alternative; monitor sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Esketamine?
MediHelp rates the interaction as moderate. Brompheniramine and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating antihistamine, and with esketamine may increase drowsiness and impair alertness and coordination.
How serious is the interaction between Brompheniramine and Esketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid sedating antihistamines around esketamine sessions, or consider a non-sedating alternative; monitor sedation.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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