Drug interactions
Brompheniramine + Fentanyl intranasal
Severity: Moderate
Brompheniramine and Fentanyl intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an opioid with a sedating anticholinergic antihistamine increases drowsiness and may deepen respiratory depression. The anticholinergic effect of brompheniramine can also worsen opioid-related constipation and urinary retention.
What this interaction means in plain words
Brompheniramine and Fentanyl intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression from opioid agonism and H1 blockade, plus additive antimuscarinic effects on gut and bladder.
What to do
Monitor sedation and respiratory rate, and use the lowest effective doses. Watch for constipation and urinary retention and treat early.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Fentanyl intranasal?
MediHelp rates the interaction as moderate. Brompheniramine and Fentanyl intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an opioid with a sedating anticholinergic antihistamine increases drowsiness and may deepen respiratory depression. The anticholinergic effect of brompheniramine can also worsen opioid-related constipation and urinary retention.
How serious is the interaction between Brompheniramine and Fentanyl intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory rate, and use the lowest effective doses. Watch for constipation and urinary retention and treat early.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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