Drug interactions
Brompheniramine + Fentanyl iontophoretic transdermal system
Severity: Moderate
Brompheniramine and Fentanyl iontophoretic transdermal system: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A sedating antihistamine taken with fentanyl can add to drowsiness and respiratory depression. Brompheniramine's anticholinergic action may also worsen constipation and urinary retention.
What this interaction means in plain words
Brompheniramine and Fentanyl iontophoretic transdermal system can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression from opioid agonism and H1 antagonism, plus additive antimuscarinic effects.
What to do
Monitor sedation and respiratory rate, particularly in opioid-naive or older patients. Consider a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Fentanyl iontophoretic transdermal system?
MediHelp rates the interaction as moderate. Brompheniramine and Fentanyl iontophoretic transdermal system can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. A sedating antihistamine taken with fentanyl can add to drowsiness and respiratory depression. Brompheniramine's anticholinergic action may also worsen constipation and urinary retention.
How serious is the interaction between Brompheniramine and Fentanyl iontophoretic transdermal system?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory rate, particularly in opioid-naive or older patients. Consider a non-sedating antihistamine.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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