Drug interactions
Brompheniramine + Flurazepam
Severity: Moderate
Brompheniramine and Flurazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are sedating, and flurazepam has long-acting active metabolites. The combination can produce prolonged drowsiness, impaired coordination and next-day impairment, increasing the risk of falls, especially in older people.
What this interaction means in plain words
Brompheniramine and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via H1 antagonism and GABA-A potentiation.
What to do
Avoid combining where possible and warn about driving and falls. Use a non-sedating antihistamine, and monitor older adults closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Flurazepam?
MediHelp rates the interaction as moderate. Brompheniramine and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are sedating, and flurazepam has long-acting active metabolites. The combination can produce prolonged drowsiness, impaired coordination and next-day impairment, increasing the risk of falls, especially in older people.
How serious is the interaction between Brompheniramine and Flurazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible and warn about driving and falls. Use a non-sedating antihistamine, and monitor older adults closely.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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