Drug interactions
Brompheniramine + Gabapentin
Severity: Moderate
Brompheniramine and Gabapentin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentin and the sedating antihistamine brompheniramine both depress the CNS. Together they can increase drowsiness, dizziness and psychomotor impairment, and rarely respiratory depression, particularly in older or frail patients and those with lung disease.
What this interaction means in plain words
Brompheniramine and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Gabapentin belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Use the lowest effective doses and advise patients to avoid driving and alcohol. Monitor for excessive sedation and respiratory depression, especially in the elderly or with COPD.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gabapentin
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Gabapentin?
MediHelp rates the interaction as moderate. Brompheniramine and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gabapentin and the sedating antihistamine brompheniramine both depress the CNS. Together they can increase drowsiness, dizziness and psychomotor impairment, and rarely respiratory depression, particularly in older or frail patients and those with lung disease.
How serious is the interaction between Brompheniramine and Gabapentin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and advise patients to avoid driving and alcohol. Monitor for excessive sedation and respiratory depression, especially in the elderly or with COPD.
What other medicines interact with Gabapentin?
MediHelp also lists interactions of Gabapentin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Gabapentin page.
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