Drug interactions
Brompheniramine + Kava
Severity: Moderate
Brompheniramine and Kava: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Kava has sedative and anxiolytic effects and can add to the drowsiness of brompheniramine. Kava has also been linked to liver toxicity, which is an additional concern with long-term use.
What this interaction means in plain words
Brompheniramine and Kava can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; kava kavalactones modulate GABA-A receptors.
What to do
Advise avoiding the combination, and avoid driving or hazardous tasks. Discourage kava use generally given hepatotoxicity concerns.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Kava?
MediHelp rates the interaction as moderate. Brompheniramine and Kava can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Kava has sedative and anxiolytic effects and can add to the drowsiness of brompheniramine. Kava has also been linked to liver toxicity, which is an additional concern with long-term use.
How serious is the interaction between Brompheniramine and Kava?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding the combination, and avoid driving or hazardous tasks. Discourage kava use generally given hepatotoxicity concerns.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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