Drug interactions
Brompheniramine + Ketamine
Severity: Moderate
Brompheniramine and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating first-generation antihistamine. With ketamine, it can increase drowsiness and impair cognition and psychomotor function.
What this interaction means in plain words
Brompheniramine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Ketamine belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 antagonism and NMDA antagonism.
What to do
Monitor sedation level and advise avoiding driving or activities requiring alertness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Ketamine?
MediHelp rates the interaction as moderate. Brompheniramine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating first-generation antihistamine. With ketamine, it can increase drowsiness and impair cognition and psychomotor function.
How serious is the interaction between Brompheniramine and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and advise avoiding driving or activities requiring alertness.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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