Drug interactions
Brompheniramine + Levorphanol
Severity: Moderate
Brompheniramine and Levorphanol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an opioid with a sedating antihistamine increases drowsiness and may deepen respiratory depression. Anticholinergic effects can also worsen constipation and urinary retention.
What this interaction means in plain words
Brompheniramine and Levorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression from opioid agonism and H1 antagonism, plus additive antimuscarinic effects.
What to do
Monitor sedation and respiratory rate and use the lowest effective doses. Prefer a non-sedating antihistamine, and monitor bowel and bladder function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brompheniramine and Levorphanol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Levorphanol?
MediHelp rates the interaction as moderate. Brompheniramine and Levorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an opioid with a sedating antihistamine increases drowsiness and may deepen respiratory depression. Anticholinergic effects can also worsen constipation and urinary retention.
How serious is the interaction between Brompheniramine and Levorphanol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory rate and use the lowest effective doses. Prefer a non-sedating antihistamine, and monitor bowel and bladder function.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
