Drug interactions
Brompheniramine + Lofepramine
Severity: Moderate
Brompheniramine and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating first-generation antihistamine with anticholinergic properties, and lofepramine is a tricyclic antidepressant with some sedative and antimuscarinic activity. Together they can add to drowsiness, impaired psychomotor performance and anticholinergic effects such as dry mouth, constipation and urinary retention.
What this interaction means in plain words
Brompheniramine and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression and additive antimuscarinic effects.
What to do
Warn the patient about drowsiness and avoid driving or operating machinery until the response is known. Monitor for anticholinergic effects, especially in older adults, and consider a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Lofepramine?
MediHelp rates the interaction as moderate. Brompheniramine and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating first-generation antihistamine with anticholinergic properties, and lofepramine is a tricyclic antidepressant with some sedative and antimuscarinic activity. Together they can add to drowsiness, impaired psychomotor performance and anticholinergic effects such as dry mouth, constipation and urinary retention.
How serious is the interaction between Brompheniramine and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about drowsiness and avoid driving or operating machinery until the response is known. Monitor for anticholinergic effects, especially in older adults, and consider a non-sedating antihistamine.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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