Drug interactions
Brompheniramine + Loprazolam
Severity: Moderate
Brompheniramine and Loprazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine and the benzodiazepine loprazolam both depress the central nervous system. Combined use can cause excessive sedation, slowed reaction time and impaired coordination, with a higher risk of falls and next-day impairment.
What this interaction means in plain words
Brompheniramine and Loprazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through histamine H1 blockade and enhancement of GABA-A activity.
What to do
Counsel the patient about additive drowsiness and avoid driving or alcohol. Use the lowest effective loprazolam dose, or choose a non-sedating antihistamine, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Loprazolam?
MediHelp rates the interaction as moderate. Brompheniramine and Loprazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine and the benzodiazepine loprazolam both depress the central nervous system. Combined use can cause excessive sedation, slowed reaction time and impaired coordination, with a higher risk of falls and next-day impairment.
How serious is the interaction between Brompheniramine and Loprazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about additive drowsiness and avoid driving or alcohol. Use the lowest effective loprazolam dose, or choose a non-sedating antihistamine, especially in older patients.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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