Drug interactions
Brompheniramine + Methylenedioxymethamphetamine
Severity: Moderate
Brompheniramine and Methylenedioxymethamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MDMA is a stimulant that causes serotonin and catecholamine release, whereas brompheniramine is sedating and anticholinergic. Anticholinergic effects may add to MDMA-related tachycardia and hyperthermia, and sedation may mask intoxication. The overall interaction is poorly characterized.
What this interaction means in plain words
Brompheniramine and Methylenedioxymethamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
No firmly established mechanism; opposing CNS effects and additive anticholinergic effects that impair heat dissipation.
What to do
Advise against recreational MDMA use. If exposure occurs, monitor temperature, heart rate and hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Methylenedioxymethamphetamine?
MediHelp rates the interaction as moderate. Brompheniramine and Methylenedioxymethamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MDMA is a stimulant that causes serotonin and catecholamine release, whereas brompheniramine is sedating and anticholinergic. Anticholinergic effects may add to MDMA-related tachycardia and hyperthermia, and sedation may mask intoxication. The overall interaction is poorly characterized.
How serious is the interaction between Brompheniramine and Methylenedioxymethamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against recreational MDMA use. If exposure occurs, monitor temperature, heart rate and hydration.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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