Drug interactions
Brompheniramine + Metoclopramide intranasal
Severity: Moderate
Brompheniramine and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sedating antihistamines may add to the drowsiness caused by metoclopramide. Their anticholinergic effects can also oppose metoclopramide's prokinetic action.
What this interaction means in plain words
Brompheniramine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and anticholinergic antagonism of prokinetic effect.
What to do
Warn the patient about sedation and avoid driving until response is known. Reassess the need for the antihistamine if gastric emptying symptoms persist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Brompheniramine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sedating antihistamines may add to the drowsiness caused by metoclopramide. Their anticholinergic effects can also oppose metoclopramide's prokinetic action.
How serious is the interaction between Brompheniramine and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about sedation and avoid driving until response is known. Reassess the need for the antihistamine if gastric emptying symptoms persist.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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