Drug interactions
Brompheniramine + Midazolam intranasal
Severity: Moderate
Brompheniramine and Midazolam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam is a benzodiazepine that depresses the CNS and respiration, and a sedating antihistamine can deepen and prolong that effect. Hypoventilation or oversedation is possible, especially in vulnerable patients.
What this interaction means in plain words
Brompheniramine and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression via GABA-A modulation and H1 antagonism.
What to do
Monitor respiratory rate, oxygen saturation and level of consciousness after dosing. Avoid recent sedating antihistamine use in patients at high risk of respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Midazolam intranasal?
MediHelp rates the interaction as moderate. Brompheniramine and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midazolam is a benzodiazepine that depresses the CNS and respiration, and a sedating antihistamine can deepen and prolong that effect. Hypoventilation or oversedation is possible, especially in vulnerable patients.
How serious is the interaction between Brompheniramine and Midazolam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate, oxygen saturation and level of consciousness after dosing. Avoid recent sedating antihistamine use in patients at high risk of respiratory depression.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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