Drug interactions
Brompheniramine + Olanzapine / samidorphan
Severity: Moderate
Brompheniramine and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine is sedating and has anticholinergic activity, so brompheniramine adds to drowsiness and antimuscarinic effects. This raises the risk of constipation, ileus, urinary retention and confusion.
What this interaction means in plain words
Brompheniramine and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and additive antimuscarinic effects reducing gastrointestinal motility.
What to do
Monitor bowel function and sedation, and treat constipation early. Prefer a non-sedating, non-anticholinergic antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brompheniramine and Olanzapine / samidorphan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Brompheniramine and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine is sedating and has anticholinergic activity, so brompheniramine adds to drowsiness and antimuscarinic effects. This raises the risk of constipation, ileus, urinary retention and confusion.
How serious is the interaction between Brompheniramine and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function and sedation, and treat constipation early. Prefer a non-sedating, non-anticholinergic antihistamine.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
