Drug interactions
Brompheniramine + Orphenadrine
Severity: Moderate
Brompheniramine and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine is a muscle relaxant with strong anticholinergic and sedative activity. Together with brompheniramine this can cause marked drowsiness, confusion, dry mouth, blurred vision, urinary retention and tachycardia, especially in older adults.
What this interaction means in plain words
Brompheniramine and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic and CNS depressant effects.
What to do
Monitor for anticholinergic toxicity and oversedation, and avoid in older adults where possible. Use a non-sedating antihistamine as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Orphenadrine?
MediHelp rates the interaction as moderate. Brompheniramine and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine is a muscle relaxant with strong anticholinergic and sedative activity. Together with brompheniramine this can cause marked drowsiness, confusion, dry mouth, blurred vision, urinary retention and tachycardia, especially in older adults.
How serious is the interaction between Brompheniramine and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and oversedation, and avoid in older adults where possible. Use a non-sedating antihistamine as an alternative.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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