Drug interactions
Brompheniramine + Papaveretum
Severity: Major
Brompheniramine and Papaveretum: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum is an opioid mixture containing morphine. With brompheniramine, sedation and respiratory depression may be increased, and constipation and urinary retention may worsen.
What this interaction means in plain words
Brompheniramine and Papaveretum can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression and additive antimuscarinic effects.
What to do
Monitor sedation and respiratory rate, and start with reduced doses. Avoid other sedatives and alcohol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Papaveretum?
MediHelp rates the interaction as major. Brompheniramine and Papaveretum can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Papaveretum is an opioid mixture containing morphine. With brompheniramine, sedation and respiratory depression may be increased, and constipation and urinary retention may worsen.
How serious is the interaction between Brompheniramine and Papaveretum?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory rate, and start with reduced doses. Avoid other sedatives and alcohol.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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