Drug interactions
Brompheniramine + Phenobarbital
Severity: Moderate
Brompheniramine and Phenobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital is a barbiturate with sedative and anticonvulsant effects. Combined use with brompheniramine can cause additive drowsiness and psychomotor impairment, and sedation may be prolonged.
What this interaction means in plain words
Brompheniramine and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A potentiation and histamine H1 blockade.
What to do
Counsel about drowsiness and avoid alcohol and driving. Use a non-sedating antihistamine where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Phenobarbital?
MediHelp rates the interaction as moderate. Brompheniramine and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital is a barbiturate with sedative and anticonvulsant effects. Combined use with brompheniramine can cause additive drowsiness and psychomotor impairment, and sedation may be prolonged.
How serious is the interaction between Brompheniramine and Phenobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel about drowsiness and avoid alcohol and driving. Use a non-sedating antihistamine where possible.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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