Drug interactions
Brompheniramine + Pimozide
Severity: Moderate
Brompheniramine and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating first-generation antihistamine with anticholinergic activity. With pimozide, additive drowsiness and anticholinergic effects such as dry mouth, constipation and urinary retention may occur.
What this interaction means in plain words
Brompheniramine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects from H1 and dopamine receptor blockade.
What to do
Consider a non-sedating antihistamine if one is needed. If combined, monitor for sedation and anticholinergic symptoms and counsel on driving risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Pimozide?
MediHelp rates the interaction as moderate. Brompheniramine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating first-generation antihistamine with anticholinergic activity. With pimozide, additive drowsiness and anticholinergic effects such as dry mouth, constipation and urinary retention may occur.
How serious is the interaction between Brompheniramine and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-sedating antihistamine if one is needed. If combined, monitor for sedation and anticholinergic symptoms and counsel on driving risk.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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