Drug interactions
Brompheniramine + Quazepam
Severity: Moderate
Brompheniramine and Quazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a sedating antihistamine with a benzodiazepine hypnotic increases drowsiness and impairs psychomotor performance and next-day alertness. Falls and accidents are more likely, especially in older adults.
What this interaction means in plain words
Brompheniramine and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via H1-receptor blockade and GABA-A potentiation.
What to do
Avoid or minimize concurrent use, and counsel patients about driving and operating machinery. Use a non-sedating antihistamine where possible and consider a lower quazepam dose in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Quazepam?
MediHelp rates the interaction as moderate. Brompheniramine and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a sedating antihistamine with a benzodiazepine hypnotic increases drowsiness and impairs psychomotor performance and next-day alertness. Falls and accidents are more likely, especially in older adults.
How serious is the interaction between Brompheniramine and Quazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or minimize concurrent use, and counsel patients about driving and operating machinery. Use a non-sedating antihistamine where possible and consider a lower quazepam dose in older adults.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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