Drug interactions
Brompheniramine + Triazolam
Severity: Moderate
Brompheniramine and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a sedating antihistamine with triazolam increases drowsiness and impairs psychomotor function and memory. Falls and accidents are more likely, especially in older adults.
What this interaction means in plain words
Brompheniramine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via H1-receptor blockade and GABA-A potentiation.
What to do
Avoid or minimize concomitant use and counsel patients about driving. Prefer a non-sedating antihistamine and use the lowest effective triazolam dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Triazolam?
MediHelp rates the interaction as moderate. Brompheniramine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a sedating antihistamine with triazolam increases drowsiness and impairs psychomotor function and memory. Falls and accidents are more likely, especially in older adults.
How serious is the interaction between Brompheniramine and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or minimize concomitant use and counsel patients about driving. Prefer a non-sedating antihistamine and use the lowest effective triazolam dose.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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