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Drug interactions

Budesonide + Mesterolone

Severity: Minor

Budesonide and Mesterolone: minor interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Androgens such as mesterolone can promote sodium and fluid retention, and corticosteroids do the same. Used together, they may add to each other's effect and increase the risk of edema, particularly in patients with heart, kidney or liver disease. With inhaled or locally acting budesonide the effect is small.

What this interaction means in plain words

Budesonide and Mesterolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.

Budesonide belongs to Respiratory; Mesterolone belongs to Endocrine.

Evidence level: Low

Why it happens

Additive sodium and water retention through androgenic and mineralocorticoid-type effects.

What to do

Monitor body weight and look for peripheral edema, especially in patients with heart failure, renal impairment or hypertension. Reduce the dose or review therapy if fluid retention develops.

What to ask your pharmacist

  • Is there anything I should notice while taking both?
  • Do I need to tell my doctor at the next visit?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Budesonide with Mesterolone?

MediHelp rates the interaction as minor. Budesonide and Mesterolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Androgens such as mesterolone can promote sodium and fluid retention, and corticosteroids do the same. Used together, they may add to each other's effect and increase the risk of edema, particularly in patients with heart, kidney or liver disease. With inhaled or locally acting budesonide the effect is small.

How serious is the interaction between Budesonide and Mesterolone?

MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor body weight and look for peripheral edema, especially in patients with heart failure, renal impairment or hypertension. Reduce the dose or review therapy if fluid retention develops.

What other medicines interact with Budesonide?

MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.

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