Drug interactions
Cyclosporin + Mesterolone
Severity: Moderate
Cyclosporin and Mesterolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgens have been reported to raise cyclosporine concentrations, which may increase nephrotoxicity and hepatotoxicity. Androgens themselves can also cause liver effects.
What this interaction means in plain words
Cyclosporin and Mesterolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Mesterolone belongs to Endocrine.
Why it happens
Androgens are thought to inhibit hepatic CYP3A4 metabolism of cyclosporine, although evidence for mesterolone specifically is limited.
What to do
Monitor cyclosporine trough levels, liver enzymes and serum creatinine when starting or stopping mesterolone. Adjust the cyclosporine dose based on levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Mesterolone
Frequently asked questions
Can I take Cyclosporin with Mesterolone?
MediHelp rates the interaction as moderate. Cyclosporin and Mesterolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgens have been reported to raise cyclosporine concentrations, which may increase nephrotoxicity and hepatotoxicity. Androgens themselves can also cause liver effects.
How serious is the interaction between Cyclosporin and Mesterolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels, liver enzymes and serum creatinine when starting or stopping mesterolone. Adjust the cyclosporine dose based on levels.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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