Drug interactions
Carbamazepine + Mesterolone
Severity: Moderate
Carbamazepine and Mesterolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgens may raise carbamazepine concentrations and could cause toxicity. Evidence for mesterolone itself is limited and mostly extrapolated from other androgens.
What this interaction means in plain words
Carbamazepine and Mesterolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Mesterolone belongs to Endocrine.
Why it happens
Possible inhibition of CYP3A4-mediated carbamazepine metabolism, not firmly established for mesterolone.
What to do
Check carbamazepine levels and watch for dizziness, ataxia, diplopia and nausea when mesterolone is started. Lower the carbamazepine dose if levels are high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Mesterolone
Frequently asked questions
Can I take Carbamazepine with Mesterolone?
MediHelp rates the interaction as moderate. Carbamazepine and Mesterolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgens may raise carbamazepine concentrations and could cause toxicity. Evidence for mesterolone itself is limited and mostly extrapolated from other androgens.
How serious is the interaction between Carbamazepine and Mesterolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check carbamazepine levels and watch for dizziness, ataxia, diplopia and nausea when mesterolone is started. Lower the carbamazepine dose if levels are high.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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