Drug interactions
Budesonide + Oxaprozin
Severity: Moderate
Budesonide and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a corticosteroid with an NSAID increases the risk of GI ulceration and bleeding. The risk is greater in older patients and with prolonged therapy.
What this interaction means in plain words
Budesonide and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide belongs to Respiratory; Oxaprozin belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic effects: NSAID prostaglandin inhibition reduces mucosal protection while corticosteroids impair mucosal repair.
What to do
Use the lowest effective oxaprozin dose and consider a proton pump inhibitor for patients at GI risk. Monitor for signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Budesonide with Oxaprozin?
MediHelp rates the interaction as moderate. Budesonide and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a corticosteroid with an NSAID increases the risk of GI ulceration and bleeding. The risk is greater in older patients and with prolonged therapy.
How serious is the interaction between Budesonide and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective oxaprozin dose and consider a proton pump inhibitor for patients at GI risk. Monitor for signs of GI bleeding.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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