Drug interactions
Budesonide + Secobarbital
Severity: Moderate
Budesonide and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are CYP3A4 inducers and can reduce corticosteroid exposure, as shown with other corticosteroids. Budesonide efficacy may be reduced, especially with oral formulations that undergo extensive first-pass metabolism.
What this interaction means in plain words
Budesonide and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide belongs to Respiratory; Secobarbital belongs to Central Nervous System.
Why it happens
Secobarbital induces CYP3A4, increasing budesonide metabolism.
What to do
Monitor for reduced budesonide effect and increase the dose if disease control worsens. Reassess the dose if the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Budesonide and Secobarbital, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Budesonide
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Budesonide with Secobarbital?
MediHelp rates the interaction as moderate. Budesonide and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates are CYP3A4 inducers and can reduce corticosteroid exposure, as shown with other corticosteroids. Budesonide efficacy may be reduced, especially with oral formulations that undergo extensive first-pass metabolism.
How serious is the interaction between Budesonide and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced budesonide effect and increase the dose if disease control worsens. Reassess the dose if the barbiturate is stopped.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
