Drug interactions
Budesonide + Tolbutamide
Severity: Minor
Budesonide and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Budesonide can raise blood glucose and reduce the effect of tolbutamide. The effect is greater with oral or high-dose budesonide than with inhaled forms.
What this interaction means in plain words
Budesonide and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Budesonide belongs to Respiratory; Tolbutamide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through corticosteroid-induced hyperglycemia.
What to do
Monitor blood glucose when budesonide is started or stopped, and adjust the sulfonylurea dose as needed. Watch for hypoglycemia when the steroid is withdrawn.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Budesonide
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Budesonide with Tolbutamide?
MediHelp rates the interaction as minor. Budesonide and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Budesonide can raise blood glucose and reduce the effect of tolbutamide. The effect is greater with oral or high-dose budesonide than with inhaled forms.
How serious is the interaction between Budesonide and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when budesonide is started or stopped, and adjust the sulfonylurea dose as needed. Watch for hypoglycemia when the steroid is withdrawn.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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