Drug interactions
Budesonide-formoterol + Dichlorphenamide
Severity: Moderate
Budesonide-formoterol and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide promotes urinary potassium loss and causes metabolic acidosis, while formoterol shifts potassium into cells. Together they can cause or worsen hypokalemia, which is arrhythmogenic and may aggravate the condition being treated, such as periodic paralysis.
What this interaction means in plain words
Budesonide-formoterol and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide-formoterol belongs to Respiratory; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Additive hypokalemia from carbonic anhydrase inhibition-related renal potassium wasting and beta-2 agonist intracellular potassium shift.
What to do
Monitor serum potassium and bicarbonate at baseline and regularly during combined use. Replace potassium and adjust therapy if hypokalemia or acidosis develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Budesonide-formoterol with Dichlorphenamide?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide promotes urinary potassium loss and causes metabolic acidosis, while formoterol shifts potassium into cells. Together they can cause or worsen hypokalemia, which is arrhythmogenic and may aggravate the condition being treated, such as periodic paralysis.
How serious is the interaction between Budesonide-formoterol and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate at baseline and regularly during combined use. Replace potassium and adjust therapy if hypokalemia or acidosis develops.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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