Drug interactions
Budesonide-formoterol + Donepezil
Severity: Moderate
Budesonide-formoterol and Donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil has been associated with QT prolongation and torsades de pointes, and formoterol can also prolong the QTc, especially at high doses or with hypokalemia. Combined use may add to arrhythmia risk, and donepezil-induced bradycardia may aggravate this.
What this interaction means in plain words
Budesonide-formoterol and Donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide-formoterol belongs to Respiratory; Donepezil belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation through different mechanisms.
What to do
Consider an ECG in patients with cardiac risk factors and keep potassium and magnesium normal. Avoid exceeding labeled formoterol doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Budesonide-formoterol with Donepezil?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Donepezil has been associated with QT prolongation and torsades de pointes, and formoterol can also prolong the QTc, especially at high doses or with hypokalemia. Combined use may add to arrhythmia risk, and donepezil-induced bradycardia may aggravate this.
How serious is the interaction between Budesonide-formoterol and Donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an ECG in patients with cardiac risk factors and keep potassium and magnesium normal. Avoid exceeding labeled formoterol doses.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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