Drug interactions
Budesonide-formoterol + Epinephrine
Severity: Moderate
Budesonide-formoterol and Epinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine and formoterol are both adrenergic agonists that increase heart rate and can provoke arrhythmias and hypokalemia. Together their cardiovascular stimulation is additive, with risks of tachycardia, hypertension, palpitations and QT effects.
What this interaction means in plain words
Budesonide-formoterol and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide-formoterol belongs to Respiratory; Epinephrine belongs to Endocrine.
Why it happens
Additive beta-adrenergic stimulation with potassium shifts into cells and possible QT effects.
What to do
Do not withhold epinephrine in anaphylaxis, but monitor heart rhythm, blood pressure and potassium. Avoid routine concurrent use of other sympathomimetics where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Budesonide-formoterol with Epinephrine?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine and formoterol are both adrenergic agonists that increase heart rate and can provoke arrhythmias and hypokalemia. Together their cardiovascular stimulation is additive, with risks of tachycardia, hypertension, palpitations and QT effects.
How serious is the interaction between Budesonide-formoterol and Epinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not withhold epinephrine in anaphylaxis, but monitor heart rhythm, blood pressure and potassium. Avoid routine concurrent use of other sympathomimetics where possible.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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