Drug interactions
Budesonide-formoterol + Lofepramine
Severity: Moderate
Budesonide-formoterol and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine, a tricyclic antidepressant, can prolong the QT interval and potentiate adrenergic cardiovascular effects of beta-agonists. With formoterol this may cause tachycardia, palpitations and arrhythmia.
What this interaction means in plain words
Budesonide-formoterol and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation and tricyclic potentiation of adrenergic stimulation through inhibited norepinephrine reuptake.
What to do
Monitor heart rate, rhythm and ECG in patients with cardiac disease, and correct potassium. Use the lowest effective formoterol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Frequently asked questions
Can I take Budesonide-formoterol with Lofepramine?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine, a tricyclic antidepressant, can prolong the QT interval and potentiate adrenergic cardiovascular effects of beta-agonists. With formoterol this may cause tachycardia, palpitations and arrhythmia.
How serious is the interaction between Budesonide-formoterol and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and ECG in patients with cardiac disease, and correct potassium. Use the lowest effective formoterol dose.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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