Drug interactions
Budesonide-formoterol + Methyclothiazide
Severity: Moderate
Budesonide-formoterol and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both formoterol and thiazide diuretics can lower serum potassium, so together they may cause clinically significant hypokalemia. Low potassium raises the risk of cardiac arrhythmias, particularly in patients with heart disease or on other QT-prolonging drugs.
What this interaction means in plain words
Budesonide-formoterol and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia: beta-2 agonism shifts potassium into cells while thiazides increase renal potassium loss.
What to do
Check serum potassium and magnesium at baseline and periodically, especially when starting therapy or during acute exacerbations. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Frequently asked questions
Can I take Budesonide-formoterol with Methyclothiazide?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both formoterol and thiazide diuretics can lower serum potassium, so together they may cause clinically significant hypokalemia. Low potassium raises the risk of cardiac arrhythmias, particularly in patients with heart disease or on other QT-prolonging drugs.
How serious is the interaction between Budesonide-formoterol and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium at baseline and periodically, especially when starting therapy or during acute exacerbations. Replace potassium as needed.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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