Drug interactions
Budesonide-formoterol + Mobocertinib
Severity: Major
Budesonide-formoterol and Mobocertinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib carries a boxed warning for QTc prolongation and torsades de pointes. Formoterol may add to this effect and lower potassium.
What this interaction means in plain words
Budesonide-formoterol and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QTc prolongation, with beta-agonist induced hypokalemia.
What to do
Avoid if possible and use an alternative bronchodilator. If necessary, monitor ECG and electrolytes frequently and reduce mobocertinib per labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Budesonide-formoterol
Frequently asked questions
Can I take Budesonide-formoterol with Mobocertinib?
MediHelp rates the interaction as major. Budesonide-formoterol and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mobocertinib carries a boxed warning for QTc prolongation and torsades de pointes. Formoterol may add to this effect and lower potassium.
How serious is the interaction between Budesonide-formoterol and Mobocertinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and use an alternative bronchodilator. If necessary, monitor ECG and electrolytes frequently and reduce mobocertinib per labeling.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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