Drug interactions
Budesonide-formoterol + Phenoxybenzamine
Severity: Moderate
Budesonide-formoterol and Phenoxybenzamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenoxybenzamine causes alpha-adrenergic blockade and vasodilation, while formoterol causes beta-2 mediated vasodilation and reflex tachycardia. Together they may produce hypotension and a pronounced reflex rise in heart rate.
What this interaction means in plain words
Budesonide-formoterol and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilatory effects from alpha blockade and beta-2 stimulation, with reflex tachycardia.
What to do
Monitor blood pressure and heart rate, particularly after dose changes or at initiation, and advise patients about postural symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Frequently asked questions
Can I take Budesonide-formoterol with Phenoxybenzamine?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenoxybenzamine causes alpha-adrenergic blockade and vasodilation, while formoterol causes beta-2 mediated vasodilation and reflex tachycardia. Together they may produce hypotension and a pronounced reflex rise in heart rate.
How serious is the interaction between Budesonide-formoterol and Phenoxybenzamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, particularly after dose changes or at initiation, and advise patients about postural symptoms.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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