Drug interactions
Budesonide-formoterol + Sacubitril / valsartan
Severity: Minor
Budesonide-formoterol and Sacubitril / valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan can raise serum potassium, while formoterol tends to lower it by shifting potassium into cells. The effects oppose each other, so the net change is unpredictable and has little clinical importance for most patients.
What this interaction means in plain words
Budesonide-formoterol and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Angiotensin receptor blockade reduces aldosterone-mediated potassium excretion, whereas beta-2 agonism drives potassium into cells through Na/K-ATPase stimulation.
What to do
No routine action is needed. Check potassium in patients with renal impairment or heart failure, or when high-dose or frequent formoterol is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Budesonide-formoterol
Frequently asked questions
Can I take Budesonide-formoterol with Sacubitril / valsartan?
MediHelp rates the interaction as minor. Budesonide-formoterol and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan can raise serum potassium, while formoterol tends to lower it by shifting potassium into cells. The effects oppose each other, so the net change is unpredictable and has little clinical importance for most patients.
How serious is the interaction between Budesonide-formoterol and Sacubitril / valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Check potassium in patients with renal impairment or heart failure, or when high-dose or frequent formoterol is used.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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