Drug interactions
Budesonide-formoterol + Umeclidinium bromide / vilanterol inhaled
Severity: Major
Budesonide-formoterol and Umeclidinium bromide / vilanterol inhaled: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both formoterol and vilanterol are long-acting beta-agonists, so combining them duplicates therapy and increases beta-adrenergic effects such as tachycardia, tremor, hypokalemia and QT prolongation. There is no added benefit and cardiovascular risk rises.
What this interaction means in plain words
Budesonide-formoterol and Umeclidinium bromide / vilanterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Duplicate long-acting beta2-agonist activity with additive cardiovascular and hypokalemic effects.
What to do
Avoid using two LABA-containing products together and choose a single regimen. If the patient has been on both, stop one and monitor heart rate and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Budesonide-formoterol
Frequently asked questions
Can I take Budesonide-formoterol with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as major. Budesonide-formoterol and Umeclidinium bromide / vilanterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both formoterol and vilanterol are long-acting beta-agonists, so combining them duplicates therapy and increases beta-adrenergic effects such as tachycardia, tremor, hypokalemia and QT prolongation. There is no added benefit and cardiovascular risk rises.
How serious is the interaction between Budesonide-formoterol and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two LABA-containing products together and choose a single regimen. If the patient has been on both, stop one and monitor heart rate and potassium.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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