Drug interactions
Bupivacaine + Pindolol
Severity: Moderate
Bupivacaine and Pindolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupivacaine can cause hypotension and bradycardia, particularly with neuraxial block or high systemic levels, and pindolol may add to these effects. Cardiac depression from bupivacaine may also be harder to treat in a beta-blocked patient.
What this interaction means in plain words
Bupivacaine and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive negative chronotropic, inotropic and hypotensive effects from beta blockade and local anesthetic sodium channel blockade.
What to do
Use the lowest effective bupivacaine dose and monitor ECG, heart rate and blood pressure. Have vasopressors and anticholinergics available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupivacaine
- Bupivacaine + Bupivacaine implant Major
- Amlodipine-benazepril + Bupivacaine Moderate
- Benazepril + Bupivacaine Moderate
- Bupivacaine + Bupivacaine liposome Moderate
- Bupivacaine + Captopril Moderate
- Bupivacaine + Dofetilide Moderate
Frequently asked questions
Can I take Bupivacaine with Pindolol?
MediHelp rates the interaction as moderate. Bupivacaine and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupivacaine can cause hypotension and bradycardia, particularly with neuraxial block or high systemic levels, and pindolol may add to these effects. Cardiac depression from bupivacaine may also be harder to treat in a beta-blocked patient.
How serious is the interaction between Bupivacaine and Pindolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective bupivacaine dose and monitor ECG, heart rate and blood pressure. Have vasopressors and anticholinergics available.
What other medicines interact with Bupivacaine?
MediHelp also lists interactions of Bupivacaine with, for example, Bupivacaine implant, Amlodipine-benazepril, Benazepril. The full list is on the Bupivacaine page.
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