Drug interactions
Benazepril + Bupivacaine
Severity: Moderate
Benazepril and Bupivacaine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupivacaine, especially when given epidurally or spinally, causes sympathetic blockade and hypotension. Patients on ACE inhibitors may experience more pronounced or refractory hypotension.
What this interaction means in plain words
Benazepril and Bupivacaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Bupivacaine belongs to Central Nervous System.
Why it happens
Additive hypotension from regional sympathetic blockade and suppression of angiotensin II-mediated vascular tone.
What to do
Monitor blood pressure closely during neuraxial or regional anesthesia and be prepared with fluids and vasopressors; consider holding the ACE inhibitor before planned procedures per local protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Bupivacaine
- Bupivacaine + Bupivacaine implant Major
- Amlodipine-benazepril + Bupivacaine Moderate
- Bupivacaine + Bupivacaine liposome Moderate
- Bupivacaine + Captopril Moderate
- Bupivacaine + Dofetilide Moderate
- Bupivacaine + Iloprost Moderate
Frequently asked questions
Can I take Benazepril with Bupivacaine?
MediHelp rates the interaction as moderate. Benazepril and Bupivacaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupivacaine, especially when given epidurally or spinally, causes sympathetic blockade and hypotension. Patients on ACE inhibitors may experience more pronounced or refractory hypotension.
How serious is the interaction between Benazepril and Bupivacaine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during neuraxial or regional anesthesia and be prepared with fluids and vasopressors; consider holding the ACE inhibitor before planned procedures per local protocol.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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